Rossier A, Bullani R, Burnier M, Teta D
Service de néphrologie, Département de médecine interne, CHUV, Lausanne.
Rev Med Suisse. 2011 Mar 2;7(284):478-82.
Metabolic acidosis is a prevalent complication in moderate and late stages of chronic kidney disease (CKD). It is established that the correction of metabolic acidosis may improve metabolic bone disorders and protein degradation in the skeletal muscle, two characteristic complications of patients with advanced CKD. In the last 18 months, three randomized controlled trials have drawn the attention on a novel indication to correct metabolic acidosis in these patients, i.e., halting CKD progression. These data show that sodium bicarbonate, a cheap and easily manageable treatment, may delay the progression of CKD and the need of a renal replacement therapy such as dialysis or kidney transplantation.
代谢性酸中毒是慢性肾脏病（CKD）中晚期常见的并发症。已证实，纠正代谢性酸中毒可能改善代谢性骨病和骨骼肌中的蛋白质降解，这是晚期CKD患者的两个典型并发症。在过去18个月里，三项随机对照试验引起了人们对纠正这些患者代谢性酸中毒的新适应症的关注，即阻止CKD进展。这些数据表明，碳酸氢钠作为一种廉价且易于管理的治疗方法，可能会延缓CKD的进展以及减少诸如透析或肾移植等肾脏替代治疗的需求。
