Alcohol and Drug Abuse Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Exp Clin Psychopharmacol. 2011 Apr;19(2):131-3. doi: 10.1037/a0023037.
This report describes a novel procedure for computer-controlled drug-dose determination for IV drug self-administration studies. By modifying the duration of each infusion of a single concentration of a drug solution, five or more unit doses (mg/kg/inj) can be dispensed from the same syringe. The advantages of this procedure include the following: (a) it is not necessary to prepare a new syringe for each dose change, (b) the sterility of the IV catheter line is broken less often and, (c) the confounding effect of flushing through the catheter line with the previous drug dose is avoided. This procedure is accurate and reliable and can be applied to multiple sessions of any duration across days or weeks.
本报告介绍了一种用于计算机控制药物剂量确定的新方法，用于 IV 药物自我给药研究。通过修改单次输注单一浓度药物溶液的持续时间，可以从同一注射器中分配五个或更多个单位剂量（mg/kg/inj）。该程序的优点包括：(a) 不必为每次剂量变化准备新的注射器，(b) IV 导管线路的无菌性破坏频率降低，以及 (c) 避免了用先前药物剂量冲洗导管线路的混杂效应。该程序准确可靠，可适用于多天或数周内任何时长的多次治疗。
