Sieroszewski Piotr, Wierzbicka Dorota, Bober Lukasz, Perenc Małgorzata
Fetal Medicine and Gynecology Department, Medical University of Łódź, Poland.
J Matern Fetal Neonatal Med. 2011 Jul;24(7):904-6. doi: 10.3109/14767058.2010.536864. Epub 2011 Apr 4.
The presence of the uterine leiomyomas may change the concentrations of the screening serum markers and so after the risk calculation of the fetal chromosomal abnormalities.
To estimate the influence of the uterine leiomyomas on the first and second trimester serum markers concentrations.
The studied group consisted of 127 women between 11 and 20 weeks of normal singleton pregnancy. In each patient, the uterine leiomyomas were diagnosed - over 20 mm in the diameter and located in the uterine wall. Seventy-seven patients had undergone the first trimester screening, 50 patients the second trimester screening. The control group consisted of 1020 women between 11 and 20 weeks of normal singleton pregnancy without uterine leiomyomas.
In the first trimester group, the pregnancy-associated plasma protein A serum concentrations were not different from the controls. The median concentrations of free beta-human chorionic gonadotrophin (β-hCG) were significantly higher (1.43 MoM). In the second trimester group, no significant differences in AFP and estriol median concentrations were observed, while the median value for free β-hCG was significantly higher (2.01 MoM) than in control group.
The presence of the uterine leiomyomas may increase maternal serum concentration of the β-hCG and so after the rate of the false positive results of the prenatal screening tests.
子宫平滑肌瘤的存在可能会改变筛查血清标志物的浓度，进而影响胎儿染色体异常风险的计算。
评估子宫平滑肌瘤对孕早期和孕中期血清标志物浓度的影响。
研究组由127例单胎正常妊娠11至20周的女性组成。每位患者均诊断出子宫平滑肌瘤，直径超过20毫米，位于子宫壁。77例患者进行了孕早期筛查，50例患者进行了孕中期筛查。对照组由1020例单胎正常妊娠11至20周且无子宫平滑肌瘤的女性组成。
在孕早期组中，妊娠相关血浆蛋白A血清浓度与对照组无差异。游离β-人绒毛膜促性腺激素（β-hCG）的中位数浓度显著更高（1.43倍中位数倍数）。在孕中期组中，未观察到甲胎蛋白和雌三醇中位数浓度有显著差异，而游离β-hCG的中位数显著高于对照组（2.01倍中位数倍数）。
子宫平滑肌瘤的存在可能会增加母体血清β-hCG浓度，从而增加产前筛查试验假阳性结果的发生率。
