Unidad de Microbiología Clínica, Laboratorio Regional de Salud Pública de Comunidad de Madrid, Madrid, Spain.
Clin Microbiol Infect. 2011 Jul;17(7):1094-8. doi: 10.1111/j.1469-0691.2011.03495.x. Epub 2011 Apr 5.
From July 2007 to June 2009, all pneumococci causing invasive pneumococcal disease in our hospital were serotyped. Antimicrobial susceptibility was determined by microdilution. Molecular typing was performed by pulsed-field gel electrophoresis and by multilocus sequence typing. Among 251 invasive pneumococci, serotype 8 was the most frequent (13.5%). All serotype 8 strains were susceptible to penicillin; however, 61.8% (21/34) were co-resistant to erythromycin, levofloxacin and tetracycline and identical to the Sweden(15A) -ST63 clone. Serotype 8 was significantly more frequent among human immunodeficiency virus (HIV)-infected patients (36.5%). The high prevalence of this non-conjugate vaccine multiresistant serotype 8 is a cause for concern mainly in HIV-infected patients.
从 2007 年 7 月至 2009 年 6 月，我们医院所有引起侵袭性肺炎球菌病的肺炎球菌均进行了血清分型。药敏试验采用微量稀释法，分子分型采用脉冲场凝胶电泳和多位点序列分型。在 251 株侵袭性肺炎球菌中，血清型 8 最为常见（13.5%）。所有血清型 8 菌株均对青霉素敏感；然而，61.8%（21/34）对红霉素、左氧氟沙星和四环素同时耐药，与瑞典（15A）-ST63 克隆相同。血清型 8 在人类免疫缺陷病毒（HIV）感染患者中更为常见（36.5%）。这种非结合疫苗多耐药血清型 8 的高流行率主要引起 HIV 感染患者的关注。
