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Comparison of gene expression from transgenes and endogenous genes with or without introns reveals a time-regulating role of introns in natural biological systems.

摘要

比较转基因和内源性基因的表达，无论是否有内含子，都揭示了内含子在自然生物系统中的时间调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b03/3129665/b20d465d597c/gb-2011-12-3-107-1.jpg

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1

Control of endogenous gene expression timing by introns.通过内含子控制内源性基因表达的时间。

Genome Biol. 2011;12(3):107. doi: 10.1186/gb-2011-12-3-107. Epub 2011 Mar 29.

2

Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.通过减少 Hes7 基因中的内含子数量来加速分割时钟的节奏。

Cell Rep. 2013 Jan 31;3(1):1-7. doi: 10.1016/j.celrep.2012.11.012. Epub 2012 Dec 7.

3

Intronic delay is essential for oscillatory expression in the segmentation clock.内含子延迟是节段时钟振荡表达所必需的。

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3300-5. doi: 10.1073/pnas.1014418108. Epub 2011 Feb 7.

4

Why eukaryotic cells use introns to enhance gene expression: splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity.真核细胞为什么要用内含子来增强基因表达：剪接通过抑制拓扑异构酶 I 的切割活性来减少转录相关的突变。

Biol Direct. 2011 May 18;6:24. doi: 10.1186/1745-6150-6-24.

5

Intron splicing suppresses RNA silencing in Arabidopsis.内含子剪接抑制拟南芥中的 RNA 沉默。

Plant J. 2011 Oct;68(1):159-67. doi: 10.1111/j.1365-313X.2011.04676.x. Epub 2011 Aug 5.

6

DNA methylation of germ-cell-specific basic helix-loop-helix (HLH) transcription factors, Sohlh2 and Figlα during gametogenesis.生殖细胞特异性碱性螺旋-环-螺旋（HLH）转录因子 Sohlh2 和 Figlα 在配子发生过程中的 DNA 甲基化。

Mol Hum Reprod. 2011 Sep;17(9):550-61. doi: 10.1093/molehr/gar017. Epub 2011 Mar 22.

7

The enduring mystery of intron-mediated enhancement.内含子介导增强作用的持久谜团。

Plant Sci. 2015 Aug;237:8-15. doi: 10.1016/j.plantsci.2015.04.017. Epub 2015 Apr 30.

8

Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.全基因组转录谱分析揭示了新型乳腺癌相关内含子正义RNA。

PLoS One. 2015 Mar 23;10(3):e0120296. doi: 10.1371/journal.pone.0120296. eCollection 2015.

9

Transgene-Like Animal Models Using Intronic MicroRNAs.使用内含子微小RNA的转基因样动物模型。

Methods Mol Biol. 2018;1733:239-254. doi: 10.1007/978-1-4939-7601-0_20.

10

The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus.基本螺旋-环-螺旋转录因子 CrMYC2 控制茉莉酸响应的 ORCA 基因的表达，这些基因调节长春花生物碱的生物合成。

Plant J. 2011 Jul;67(1):61-71. doi: 10.1111/j.1365-313X.2011.04575.x. Epub 2011 Apr 26.

引用本文的文献

1

Jasmonate signalling pathway in strawberry: Genome-wide identification, molecular characterization and expression of JAZs and MYCs during fruit development and ripening.草莓茉莉酸信号通路：在果实发育和成熟过程中 JAZs 和 MYCs 的全基因组鉴定、分子特征和表达。

PLoS One. 2018 May 10;13(5):e0197118. doi: 10.1371/journal.pone.0197118. eCollection 2018.

2

AOX1-Subfamily Gene Members in Olea europaea cv. "Galega Vulgar"-Gene Characterization and Expression of Transcripts during IBA-Induced in Vitro Adventitious Rooting.油橄榄 cv. “Galega Vulgar”-IBA 诱导离体不定根形成过程中 AOX1 亚家族基因成员的基因特征和转录本表达。

Int J Mol Sci. 2018 Feb 17;19(2):597. doi: 10.3390/ijms19020597.

3

本文引用的文献

1

Intronic delay is essential for oscillatory expression in the segmentation clock.内含子延迟是节段时钟振荡表达所必需的。

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3300-5. doi: 10.1073/pnas.1014418108. Epub 2011 Feb 7.

2

Segment number and axial identity in a segmentation clock period mutant.在一个分段时钟周期突变体中，分段编号和轴向身份。

Curr Biol. 2010 Jul 27;20(14):1254-8. doi: 10.1016/j.cub.2010.05.071. Epub 2010 Jul 15.

3

Post-transcriptional controls - adding a new layer of regulation to clock gene expression.转录后调控——为时钟基因表达增添新的调控层。

通过内含子控制内源性基因表达的时间。

Control of endogenous gene expression timing by introns.

机构信息

Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden 01307, Germany.

出版信息

Genome Biol. 2011;12(3):107. doi: 10.1186/gb-2011-12-3-107. Epub 2011 Mar 29.

DOI:10.1186/gb-2011-12-3-107

PMID:21463534

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3129665/

Abstract

Comparison of gene expression from transgenes and endogenous genes with or without introns reveals a time-regulating role of introns in natural biological systems.

摘要

比较转基因和内源性基因的表达，无论是否有内含子，都揭示了内含子在自然生物系统中的时间调节作用。

相似文献

1

Control of endogenous gene expression timing by introns.通过内含子控制内源性基因表达的时间。

Genome Biol. 2011;12(3):107. doi: 10.1186/gb-2011-12-3-107. Epub 2011 Mar 29.

2

Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.通过减少 Hes7 基因中的内含子数量来加速分割时钟的节奏。

Cell Rep. 2013 Jan 31;3(1):1-7. doi: 10.1016/j.celrep.2012.11.012. Epub 2012 Dec 7.

3

Intronic delay is essential for oscillatory expression in the segmentation clock.内含子延迟是节段时钟振荡表达所必需的。

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3300-5. doi: 10.1073/pnas.1014418108. Epub 2011 Feb 7.

4

Why eukaryotic cells use introns to enhance gene expression: splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity.真核细胞为什么要用内含子来增强基因表达：剪接通过抑制拓扑异构酶 I 的切割活性来减少转录相关的突变。

Biol Direct. 2011 May 18;6:24. doi: 10.1186/1745-6150-6-24.

5

Intron splicing suppresses RNA silencing in Arabidopsis.内含子剪接抑制拟南芥中的 RNA 沉默。

Plant J. 2011 Oct;68(1):159-67. doi: 10.1111/j.1365-313X.2011.04676.x. Epub 2011 Aug 5.

6

DNA methylation of germ-cell-specific basic helix-loop-helix (HLH) transcription factors, Sohlh2 and Figlα during gametogenesis.生殖细胞特异性碱性螺旋-环-螺旋（HLH）转录因子 Sohlh2 和 Figlα 在配子发生过程中的 DNA 甲基化。

Mol Hum Reprod. 2011 Sep;17(9):550-61. doi: 10.1093/molehr/gar017. Epub 2011 Mar 22.

7

The enduring mystery of intron-mediated enhancement.内含子介导增强作用的持久谜团。

Plant Sci. 2015 Aug;237:8-15. doi: 10.1016/j.plantsci.2015.04.017. Epub 2015 Apr 30.

8

Genome-wide transcript profiling reveals novel breast cancer-associated intronic sense RNAs.全基因组转录谱分析揭示了新型乳腺癌相关内含子正义RNA。

PLoS One. 2015 Mar 23;10(3):e0120296. doi: 10.1371/journal.pone.0120296. eCollection 2015.

9

Transgene-Like Animal Models Using Intronic MicroRNAs.使用内含子微小RNA的转基因样动物模型。

Methods Mol Biol. 2018;1733:239-254. doi: 10.1007/978-1-4939-7601-0_20.

10

The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus.基本螺旋-环-螺旋转录因子 CrMYC2 控制茉莉酸响应的 ORCA 基因的表达，这些基因调节长春花生物碱的生物合成。

Plant J. 2011 Jul;67(1):61-71. doi: 10.1111/j.1365-313X.2011.04575.x. Epub 2011 Apr 26.

引用本文的文献

1

Jasmonate signalling pathway in strawberry: Genome-wide identification, molecular characterization and expression of JAZs and MYCs during fruit development and ripening.草莓茉莉酸信号通路：在果实发育和成熟过程中 JAZs 和 MYCs 的全基因组鉴定、分子特征和表达。

PLoS One. 2018 May 10;13(5):e0197118. doi: 10.1371/journal.pone.0197118. eCollection 2018.

2

AOX1-Subfamily Gene Members in Olea europaea cv. "Galega Vulgar"-Gene Characterization and Expression of Transcripts during IBA-Induced in Vitro Adventitious Rooting.油橄榄 cv. “Galega Vulgar”-IBA 诱导离体不定根形成过程中 AOX1 亚家族基因成员的基因特征和转录本表达。

Int J Mol Sci. 2018 Feb 17;19(2):597. doi: 10.3390/ijms19020597.

3

本文引用的文献

1

Intronic delay is essential for oscillatory expression in the segmentation clock.内含子延迟是节段时钟振荡表达所必需的。

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3300-5. doi: 10.1073/pnas.1014418108. Epub 2011 Feb 7.

2

Segment number and axial identity in a segmentation clock period mutant.在一个分段时钟周期突变体中，分段编号和轴向身份。

Curr Biol. 2010 Jul 27;20(14):1254-8. doi: 10.1016/j.cub.2010.05.071. Epub 2010 Jul 15.

3

Post-transcriptional controls - adding a new layer of regulation to clock gene expression.转录后调控——为时钟基因表达增添新的调控层。

Introns: The Functional Benefits of Introns in Genomes.

内含子：基因组中内含子的功能益处。

Genomics Inform. 2015 Dec;13(4):112-8. doi: 10.5808/GI.2015.13.4.112. Epub 2015 Dec 31.

4

Timing by rhythms: Daily clocks and developmental rulers.节律计时：日常时钟与发育标尺。

Dev Growth Differ. 2016 Jan;58(1):43-58. doi: 10.1111/dgd.12242. Epub 2015 Nov 6.

5

Introns and gene expression: cellular constraints, transcriptional regulation, and evolutionary consequences.内含子与基因表达：细胞限制、转录调控及进化后果

Bioessays. 2015 Feb;37(2):148-54. doi: 10.1002/bies.201400138. Epub 2014 Nov 14.

6

Conservation in first introns is positively associated with the number of exons within genes and the presence of regulatory epigenetic signals.第一内含子中的保守性与基因内的外显子数量以及调控表观遗传信号的存在呈正相关。

BMC Genomics. 2014 Jun 26;15(1):526. doi: 10.1186/1471-2164-15-526.

7

Models in biology: 'accurate descriptions of our pathetic thinking'.生物学中的模型：“对我们可悲思维的精确描述”。

BMC Biol. 2014 Apr 30;12:29. doi: 10.1186/1741-7007-12-29.

Trends Cell Biol. 2010 Sep;20(9):533-41. doi: 10.1016/j.tcb.2010.06.004. Epub 2010 Jul 12.

4

Rates of in situ transcription and splicing in large human genes.大型人类基因中的原位转录和剪接速率。

Nat Struct Mol Biol. 2009 Nov;16(11):1128-33. doi: 10.1038/nsmb.1666. Epub 2009 Oct 11.

5

Intron length increases oscillatory periods of gene expression in animal cells.内含子长度增加动物细胞中基因表达的振荡周期。

Genes Dev. 2008 Sep 1;22(17):2342-6. doi: 10.1101/gad.1696108. Epub 2008 Aug 14.

6

Intron delays and transcriptional timing during development.发育过程中的内含子延迟与转录时间

Dev Cell. 2008 Mar;14(3):324-30. doi: 10.1016/j.devcel.2008.02.002.

7

Instability of Hes7 protein is crucial for the somite segmentation clock.Hes7蛋白的不稳定性对体节分割时钟至关重要。

Nat Genet. 2004 Jul;36(7):750-4. doi: 10.1038/ng1372. Epub 2004 May 30.

8

Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator.具有转录延迟的自抑制：斑马鱼体节发生振荡器的一种简单机制。

Curr Biol. 2003 Aug 19;13(16):1398-408. doi: 10.1016/s0960-9822(03)00534-7.

9

Mechanisms of transcriptional timing in Drosophila.果蝇中转录定时的机制。

Science. 1992 Jan 3;255(5040):39-40. doi: 10.1126/science.1553530.

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深度研究

通过内含子控制内源性基因表达的时间。

Control of endogenous gene expression timing by introns.

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

通过内含子控制内源性基因表达的时间。

Control of endogenous gene expression timing by introns.

机构信息

出版信息

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引用本文的文献

本文引用的文献