嗜麦芽窄食单胞菌慢性肺部感染与囊性纤维化患者的肺功能。
Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis.
机构信息
Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
出版信息
J Cyst Fibros. 2011 Sep;10(5):318-25. doi: 10.1016/j.jcf.2011.03.006. Epub 2011 Apr 3.
BACKGROUND
The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear.
METHOD
All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2 years without any other chronic Gram-negative infection were matched to two non-infected CF controls.
RESULTS
Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2 years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV(1) compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3 years before the patients became chronically infected.
DISCUSSIONS
Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection.
背景
慢性嗜麦芽窄食单胞菌感染在囊性纤维化（CF）患者中的临床后果尚不清楚。
方法
纳入了 2008 年 1 月 1 日至 2009 年 12 月 31 日期间在哥本哈根 CF 中心接受治疗的所有患者（N=278）。所有患者均至少慢性感染嗜麦芽窄食单胞菌 2 年且无其他慢性革兰氏阴性感染。将每个慢性感染嗜麦芽窄食单胞菌的患者与两名未感染 CF 的对照患者相匹配。
结果
在 2 年的研究期间，21 名患者被慢性感染嗜麦芽窄食单胞菌。其中 15 例至少感染 2 年。与未感染 CF 的对照组相比，嗜麦芽窄食单胞菌组患者的 FEV1 下降速度更快（-3.2%/年 vs. -0.3%/年）（P=0.03）。该下降速度与患者慢性感染前 3 年的观察结果相同。
讨论
与慢性感染前相比，慢性嗜麦芽窄食单胞菌感染并不会导致肺功能下降得更快。
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