Department of Ophthalmology, Hôpital Croix-Rousse, 103 Grande Rue de la Croix-Rousse, Lyon, France.
Br J Ophthalmol. 2012 Jan;96(1):99-103. doi: 10.1136/bjo.2010.194514. Epub 2011 Apr 3.
To assess specific clinical criteria in patients with uveitis that are related to signs of sarcoidosis on (18)F-labelled fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET).
Retrospective study of 54 consecutive patients with chronic uveitis for whom a PET scan was done because of suspected sarcoidosis, between July 2004 and December 2009. All the patients underwent a clinical examination, biological tests and a high-resolution CT of the chest.
17 of the 54 patients (31.5%) presented hypermetabolic foci on (18)F-FDG-PET scan consistent with sarcoidosis. Among them eight patients (14.8%) underwent biopsy showing non-caseating granuloma. At the end of the study, 10 patients (18.5%) were considered as having a presumed sarcoidosis and seven patients (12.9%) as having indeterminate sarcoidosis. The increasing age at the diagnosis of uveitis (p=0.01), the presence of posterior synechiae (p=0.01) and a positive high-resolution CT of the chest (p=0.01) were significantly related to an abnormal PET scan.
Increasing age at the diagnosis of uveitis, the presence of posterior synechiae and the positivity of high-resolution chest CT are associated with (18)F-FDG PET scan signs consistent with sarcoidosis.
评估葡萄膜炎患者中与（18）F-氟代脱氧葡萄糖正电子发射断层扫描（（18）F-FDG-PET）上结节病迹象相关的特定临床标准。
对 2004 年 7 月至 2009 年 12 月期间因疑似结节病而进行 PET 扫描的 54 例慢性葡萄膜炎连续患者进行回顾性研究。所有患者均接受了临床检查、生物学检查和高分辨率胸部 CT 检查。
54 例患者中有 17 例（31.5%）在（18）F-FDG-PET 扫描中出现与结节病一致的高代谢病灶。其中 8 例患者（14.8%）进行了活检，显示非干酪性肉芽肿。研究结束时，10 例患者（18.5%）被认为患有疑似结节病，7 例患者（12.9%）患有不确定的结节病。葡萄膜炎诊断时年龄增大（p=0.01）、后粘连存在（p=0.01）和高分辨率胸部 CT 阳性（p=0.01）与异常 PET 扫描显著相关。
葡萄膜炎诊断时年龄增大、后粘连存在和高分辨率胸部 CT 阳性与（18）F-FDG-PET 扫描符合结节病的迹象相关。
