Department of Dermatology, Dessau Medical Center, Dessau, Germany.
Dermatology. 2011;222(2):113-8. doi: 10.1159/000325460. Epub 2011 Apr 5.
Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in agreement with eosinophilic ulcer with predominant oligoclonal CD3+ and CD30+ T lymphocytes expressing the Epstein-Barr virus membrane protein. The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder.
口腔黏膜嗜酸性溃疡是一种发病机制不明的良性病变，主要影响舌部。它被认为是对多种刺激的反应模式。我们报告了一名 12 岁男孩，他在下颌牙龈处出现无痛性浸润性溃疡，表面覆盖有坏死的黄白色腐肉。颌骨或局部淋巴结均无病理特征。组织病理学、免疫组织化学和基因重排研究均符合以寡克隆 CD3+和 CD30+T 淋巴细胞为主的嗜酸性溃疡，表达 EBV 膜蛋白。溃疡在 4 周内消退，3 年随访未见复发迹象。EBV 可能在引发这种反应性淋巴增生性疾病中发挥了作用。
