突触核蛋白 II (SYN2) 基因多态性与易感性癫痫之间缺乏关联：病例对照研究和荟萃分析。
Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy: a case-control study and meta-analysis.
机构信息
Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
Synapse. 2011 Oct;65(10):1073-9. doi: 10.1002/syn.20939. Epub 2011 May 16.
OBJECTIVE
The SYN2 rs3773364 A>G polymorphism has been proposed to be involved in susceptibility to epilepsy, but research results have been inconclusive. The aim of this study was to investigate the association between the SYN2 rs3773364 A>G polymorphism and susceptibility against epilepsy in a case-control study and a meta-analysis.
METHODS
The SYN2 rs3773364 A>G polymorphism was successfully genotyped in 1182 samples (618 epilepsy patients) of Chinese, Indian, and Malay ethnicities. Meta-analysis of the related studies, including this case-control study, was performed under alternative genetic models.
RESULTS
Data from the case-control study indicated no allelic and genotypic association of this locus with susceptibility to epilepsy in the tri-ethnic Malaysian population. Similar finding was obtained by stratified analysis by epilepsy syndrome for idiopathic epilepsy. These results were verified by meta-analysis of the related pooled data.
CONCLUSIONS
Our study indicated that SYN2 rs3773364 A>G polymorphism is not a risk factor for susceptibility to epilepsy.
目的
SYN2 rs3773364 A>G 多态性被认为与癫痫易感性有关，但研究结果尚无定论。本研究旨在通过病例对照研究和荟萃分析探讨 SYN2 rs3773364 A>G 多态性与癫痫易感性的关系。
方法
成功对来自中国、印度和马来族群的 1182 个样本（618 例癫痫患者）进行了 SYN2 rs3773364 A>G 多态性基因分型。在不同遗传模型下对包括该病例对照研究在内的相关研究进行了荟萃分析。
结果
病例对照研究数据表明，该基因座与马来西亚的三种族人群癫痫易感性无等位基因和基因型关联。对特发性癫痫的癫痫综合征进行分层分析也得到了类似的结果。相关汇总数据的荟萃分析结果也验证了这一结果。
结论
我们的研究表明，SYN2 rs3773364 A>G 多态性不是癫痫易感性的危险因素。
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