Wu Yi-Le, Yang Hui-Yun, Ding Xiu-Xiu, Zhao Xue, Chen Jian, Bi Peng, Sun Ye-Huan
Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, Anhui 230032, China.
Seizure. 2014 Jun;23(6):411-6. doi: 10.1016/j.seizure.2014.01.018. Epub 2014 Feb 2.
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been implicated as a potential risk factor for epilepsy. To date, many case-control studies have investigated the association between MTHFR C677T polymorphism and epilepsy susceptibility. However, those findings were inconsistent. The objective of this study is to evaluate the precise association between MTHFR C677T polymorphism and epilepsy.
An electronic search of PubMed, EMBASE for papers on the MTHFR C677T polymorphism and epilepsy susceptibility was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association.
Ten case-control studies containing 1713 cases and 1867 controls regarding MTHFR C677T polymorphism were selected. A significant association between the MTHFR C677T polymorphism and epilepsy susceptibility was revealed in this meta-analysis (for T vs. C: OR=1.19, 95% CI=1.08-1.32; for TT+CT vs. CC: OR=1.20, 95% CI=1.05-1.38; for TT vs. CC: OR=1.48, 95% CI=1.20-1.83; for TT vs. CT+CC: OR=1.35, 95% CI=1.12-1.64). In subgroup analysis by ethnicity, the results also indicated the association between the MTHFR C677T polymorphism and epilepsy susceptibility within the Asian populations (for T vs. C: OR=1.55, 95% CI=1.15-2.07; for TT+CT vs. CC: OR=1.67, 95% CI=1.08-2.59; for TT vs. CC: OR=2.33, 95% CI=1.30-4.20; for TT vs. CT+CC: OR=1.89, 95% CI=1.12-3.18).
The results indicated that MTHFR C677T polymorphism was associated with an increased risk of epilepsy. However, further studies in various regions are needed to confirm the findings from this meta-analysis.
亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性被认为是癫痫的一个潜在风险因素。迄今为止，许多病例对照研究调查了MTHFR C677T基因多态性与癫痫易感性之间的关联。然而，这些研究结果并不一致。本研究的目的是评估MTHFR C677T基因多态性与癫痫之间的确切关联。
通过电子检索PubMed、EMBASE数据库，查找关于MTHFR C677T基因多态性与癫痫易感性的文献。计算比值比（OR）及95%置信区间（CI）以评估两者之间的关联。
选取了10项关于MTHFR C677T基因多态性的病例对照研究，共包含1713例病例和1867例对照。该荟萃分析揭示了MTHFR C677T基因多态性与癫痫易感性之间存在显著关联（T与C相比：OR = 1.19，95%CI = 1.08 - 1.32；TT + CT与CC相比：OR = 1.20，95%CI = 1.05 - 1.38；TT与CC相比：OR = 1.48，95%CI = 1.20 - 1.83；TT与CT + CC相比：OR = 1.35，95%CI = 1.12 - 1.64）。在按种族进行的亚组分析中，结果也表明亚洲人群中MTHFR C677T基因多态性与癫痫易感性之间存在关联（T与C相比：OR = 1.55，95%CI = 1.15 - 2.07；TT + CT与CC相比：OR = 1.67，95%CI = 1.08 - 2.59；TT与CC相比：OR = 2.33，95%CI = 1.30 - 4.20；TT与CT + CC相比：OR = 1.89，95%CI = 1.12 - 3.18）。
结果表明MTHFR C677T基因多态性与癫痫风险增加有关。然而，需要在不同地区开展进一步研究以证实本荟萃分析的结果。
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