Liu Yao, Hong Lan, Yu Lu-Shan, Jiang Hui-Di, Chen Jian-Zhong, Meng Qin, Chen Shu-Qing, Zeng Su
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yao Xue Xue Bao. 2011 Jan;46(1):19-29.
New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines. The translation research will help to build an advanced R&D system from the basic laboratory research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs. In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates. ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process. Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.
新化学实体（NCEs）的研发是一个涉及多学科的系统性长期项目。转化研究将有助于构建一个从基础实验室研究、临床前研究、临床评估到药物临床应用的先进研发体系，旨在缩短研发周期并加速新药上市。在新药研发及其临床应用中，药物处置（吸收、分布、代谢、排泄，即ADME）特性是评估候选药物成药性的重要标准。NCEs的ADME评估在整个创新药物研发过程的转化研究中起着重要作用。因此，在药物设计和开发的早期阶段进行ADME评估将有助于提高成功率并降低成本，进而获得安全、有效的药物。
