Clinical and Translational Oncology Group, Fundacion Santa Fe de Bogota, Calle 119 No. 7 - 75, Bogota D.C., Colombia.
Curr Stem Cell Res Ther. 2011 Dec;6(4):339-49. doi: 10.2174/157488811797904317.
The concept that the genesis of new cells in the adult mammalian brain is negligible has long influenced our perception and understanding of the origin and development of central nervous system (CNS) tumors. The discovery that neurons and glia are produced throughout life from neural stem cells provides new possibilities for candidate precursor cells of CNS neoplasms. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis. As such, opportunities become available to identify new therapeutic strategies.
长期以来，成年哺乳动物大脑中新细胞生成微不足道的观点一直影响着我们对中枢神经系统（CNS）肿瘤起源和发展的认识和理解。新发现表明，神经元和神经胶质细胞在一生中都由神经干细胞产生，这为 CNS 肿瘤的候选前体细胞提供了新的可能性。新出现的假说认为，控制成年神经发生的细胞和遗传机制的改变可能导致脑瘤的发生。因此，为确定新的治疗策略提供了机会。
