Hashimoto K, Goromaru T
Department of Radiopharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Fukuyama, Japan.
Radioisotopes. 1990 Aug;39(8):335-41. doi: 10.3769/radioisotopes.39.8_335.
The distribution of radioactivity in the mouse brain after intravenous administration of 3H-paroxetine was in the order (highest to lowest) hypothalamus greater than cerebral cortex greater than cerebellum. The radioactivity in the hypothalamus and cerebral cortex after injection of 3H-paroxetine was significantly decreased by treatment with 6-nitroquipazine or paroxetine. HPLC and TLC analyses show that no radioactive metabolites were found in the mouse brain 3 h after intravenous administration of 3H-paroxetine. The present results indicate that 3H-paroxetine would be a suitable radioligand for in vivo study of 5-HT uptake sites in mouse brain.
静脉注射3H-帕罗西汀后，放射性在小鼠脑中的分布顺序为（从高到低）下丘脑＞大脑皮层＞小脑。注射3H-帕罗西汀后，下丘脑和大脑皮层中的放射性通过6-硝基喹哌嗪或帕罗西汀治疗显著降低。高效液相色谱法（HPLC）和薄层色谱法（TLC）分析表明，静脉注射3H-帕罗西汀3小时后，在小鼠脑中未发现放射性代谢物。目前的结果表明，3H-帕罗西汀将是用于小鼠脑内5-羟色胺摄取位点体内研究的合适放射性配体。
