Abe Naohito, Ito Tetsuro, Oyama Masayoshi, Sawa Ryuichi, Takahashi Yoshikazu, Iinuma Munekazu
Laboratory of Pharmacognosy, Gifu Pharmaceutical University, 1–25–4 Daigaku-nishi, Gifu, Japan.
Chem Pharm Bull (Tokyo). 2011;59(4):452-7. doi: 10.1248/cpb.59.452.
Three new stilbene derivatives, albiraminols A (1) (resveratrol hexamer), B (2) (resveratrol dimer), and vatalbinoside F (3) (mono-glucoside of resveratrol dimer), along with malibatol were isolated from acetone soluble portions of the stem of Vatica albiramis. The structures of the isolates were established on the basis of spectroscopic analyses, including a detailed NMR spectroscopic investigation. The biosynthetic aspects of the isolates are discussed in this paper. Compound 1 is composed of tetrameric resveratrol (vaticanol B (1A)) and dimeric resveratrol (1B) and is the first instance of the resveratrol derivative bearing a 5,6,11,12-tetrahydro-5,11-epoxydibenzo[a,e][8]annulene ring system. Compound 2 possesses a novel 4,5-dihydro-13-oxabenzo[3,4]azuleno[7,8,1-jkl]phenanthrene skeleton in the framework.
从白颜树（Vatica albiramis）茎的丙酮可溶部分分离出三种新的芪衍生物，即白颜树醇A（1）（白藜芦醇六聚体）、B（2）（白藜芦醇二聚体）和瓦塔苷F（3）（白藜芦醇二聚体的单葡萄糖苷），以及马利巴醇。基于光谱分析，包括详细的核磁共振光谱研究，确定了分离物的结构。本文讨论了分离物的生物合成方面。化合物1由四聚体白藜芦醇（白颜树醇B（1A））和二聚体白藜芦醇（1B）组成，是带有5,6,11,12-四氢-5,11-环氧二苯并[a,e][8]轮烯环系统的白藜芦醇衍生物的首例。化合物2在其骨架中具有一个新型的4,5-二氢-13-氧杂苯并[3,4]薁并[7,8,1-jkl]菲骨架。
