WD40 结构域蛋白的结构与功能。
Structure and function of WD40 domain proteins.
机构信息
Structural Genomics Consortium, University of Toronto, 101 College St., Toronto, Ontario, Canada.
出版信息
Protein Cell. 2011 Mar;2(3):202-14. doi: 10.1007/s13238-011-1018-1. Epub 2011 Apr 6.
Abstract
The WD40 domain exhibits a β-propeller architecture, often comprising seven blades. The WD40 domain is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes. In this review, we will discuss the identification, definition and architecture of the WD40 domains. WD40 domain proteins are involved in a large variety of cellular processes, in which WD40 domains function as a protein-protein or protein-DNA interaction platform. WD40 domain mediates molecular recognition events mainly through the smaller top surface, but also through the bottom surface and sides. So far, no WD40 domain has been found to display enzymatic activity. We will also discuss the different binding modes exhibited by the large versatile family of WD40 domain proteins. In the last part of this review, we will discuss how post-translational modifications are recognized by WD40 domain proteins.
摘要
WD40 结构域呈现出β-螺旋桨结构，通常由七个叶片组成。WD40 结构域是最丰富的结构域之一，也是真核生物基因组中相互作用最强的结构域之一。在这篇综述中，我们将讨论 WD40 结构域的鉴定、定义和结构。WD40 结构域蛋白参与了大量的细胞过程，其中 WD40 结构域作为蛋白质-蛋白质或蛋白质-DNA 相互作用平台发挥作用。WD40 结构域主要通过较小的顶部表面介导分子识别事件，但也通过底部表面和侧面进行介导。到目前为止，还没有发现 WD40 结构域具有酶活性。我们还将讨论 WD40 结构域蛋白家族所展示的不同结合模式。在这篇综述的最后一部分，我们将讨论 WD40 结构域蛋白如何识别翻译后修饰。
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