Kokhan V S, Bolkunov A V, Ustiugov A A, Van'kin G I, Shelkovnikova T A, Redkozubova O M, Strekalova T V, Bukhman V L, Ninkina N N, Bachurin S O
Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Jan-Feb;61(1):85-93.
Gamma(gamma)-synuclein is a member of synuclein family of cytoplasmic and predominantly neuronal proteins found only in vertebrates. Gamma-synuclein is abundant in axons and presynaptic terminals of neurons localized in brain regions involved in emotions, learning and memory. However, the role of gamma-synuclein in these brain functions was not previously assessed. We have demonstrated for the first time that the loss of gamma-synuclein results in a significant increase in the level of orientation response in novel environment and decrease in the level of state anxiety.
γ-突触核蛋白是突触核蛋白家族的成员，该家族是一类主要存在于脊椎动物神经元细胞质中的蛋白质。γ-突触核蛋白在位于参与情绪、学习和记忆的脑区的神经元轴突和突触前终末中含量丰富。然而，γ-突触核蛋白在这些脑功能中的作用此前尚未得到评估。我们首次证明，γ-突触核蛋白的缺失会导致在新环境中定向反应水平显著增加，而状态焦虑水平降低。
