Bak A A, van Vliet H H, Grobbee D E
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
Atherosclerosis. 1990 Aug;83(2-3):249-55. doi: 10.1016/0021-9150(90)90170-n.
The influence of coffee and caffeine consumption on hemostatic factors was studied in 2 randomized trials. Both studies were conducted in young, healthy adults. In the first study, 107 participants were randomly allocated to one or 3 intervention groups, drinking filtered coffee, boiled coffee or no coffee at all, respectively, for a period of 9 weeks. In the second study, 69 subjects received either 4-6 tablets containing 75 mg caffeine or the same amount of placebo tablets, while using decaffeinated coffee. In this double-blind study caffeine intake from any other source was not allowed. Blood samples for hemostatic factors were obtained at baseline and after 9 weeks of intervention. The findings indicate no effect of coffee consumption on fibrinogen, clotting factor VII activity, factor VIII antigen, protein C and protein S and also no effect of caffeine consumption on fibrinogen and factor VII activity.
在两项随机试验中研究了咖啡和咖啡因摄入对止血因子的影响。两项研究均在年轻健康的成年人中进行。在第一项研究中，107名参与者被随机分配到一个或三个干预组，分别饮用过滤咖啡、煮咖啡或完全不喝咖啡，为期9周。在第二项研究中，69名受试者服用4 - 6片含75毫克咖啡因的片剂或等量的安慰剂片剂，同时饮用脱咖啡因咖啡。在这项双盲研究中，不允许从任何其他来源摄入咖啡因。在基线和干预9周后采集用于检测止血因子的血样。研究结果表明，饮用咖啡对纤维蛋白原、凝血因子VII活性、因子VIII抗原、蛋白C和蛋白S没有影响，摄入咖啡因对纤维蛋白原和因子VII活性也没有影响。
