College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201600, China.
J Org Chem. 2011 May 20;76(10):4149-53. doi: 10.1021/jo2003715. Epub 2011 Apr 15.
Chloropyrimidine or other N-containing aromatic heterocyclic analogues can be efficiently prepared from the corresponding hydroxylated precursors under solvent-free or low-solvent conditions with equimolar or less chlorinating reagents. This high-yielding protocol allows successful preparations of multigram and kilogram batches of these important synthetic intermediates.
在无溶剂或低溶剂条件下，使用等摩尔或更少的氯化试剂，可从相应的羟基化前体中高效制备氯嘧啶或其他含氮芳杂环类似物。该高产率方案允许成功制备这些重要合成中间体的多克和千克批次。
