糖基化微阵列用于解码聚糖组。
Glycan microarrays for decoding the glycome.
机构信息
Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
Annu Rev Biochem. 2011;80:797-823. doi: 10.1146/annurev-biochem-061809-152236.
Abstract
In the last decade, glycan microarrays have revolutionized the analysis of the specificity of glycan-binding proteins (GBPs), providing information that simultaneously illuminates the biology mediated by them and decodes the informational content of the glycome. Numerous methods have emerged for arraying glycans in a "chip" format, and glycan libraries have been assembled that address the diversity of the human glycome. Such arrays have been successfully used for analysis of GBPs, which mediate mammalian biology, host-pathogen interactions, and immune recognition of glycans relevant to vaccine production and cancer antigens. This review covers the development of glycan microarrays and applications that have provided insights into the roles of mammalian and microbial GBPs.
摘要
在过去的十年中，糖基微阵列技术彻底改变了糖结合蛋白 (GBP) 特异性的分析，为它们介导的生物学提供了信息，并解码了聚糖的信息内容。已经出现了许多将聚糖排列在“芯片”格式中的方法，并且已经组装了聚糖文库，以解决人类聚糖的多样性。这些阵列已成功用于分析介导哺乳动物生物学、宿主-病原体相互作用以及对与疫苗生产和癌症抗原相关的聚糖的免疫识别的 GBP。这篇综述涵盖了糖基微阵列的发展及其应用，这些应用为哺乳动物和微生物 GBP 的作用提供了深入的了解。
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