Division of Molecular Oncology and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, via Olgettina 58, 20132 Milan, Italy.
Curr Pharm Biotechnol. 2011 Aug;12(8):1128-34. doi: 10.2174/138920111796117373.
Various peptide sequences have been discovered by selecting peptide-phage display libraries in vitro against specific receptors or in vivo in tumor-bearing animals. One class of these peptides is characterized by the presence of Asn-Gly-Asp (NGR), a structural motif that can recognize the endothelium and other cells of neoangiogenic vessels. Because of this property these peptides have been used by several investigators to deliver a variety of drugs, cytokines, nanoparticles, viruses and imaging agents to tumor blood vessels. Here we review the reports on these conjugates and discuss the structural, functional and stability properties of NGR embedded into different molecular scaffolds.
已经通过体外筛选针对特定受体的肽噬菌体展示文库或在荷瘤动物体内发现了各种肽序列。这些肽的一类特征在于存在 Asn-Gly-Asp (NGR)，这是一种可以识别内皮细胞和新血管生成的其他细胞的结构基序。由于这种特性，这些肽已被许多研究人员用于将各种药物、细胞因子、纳米颗粒、病毒和成像剂递送至肿瘤血管。在这里，我们回顾了这些缀合物的报告，并讨论了嵌入不同分子支架中的 NGR 的结构、功能和稳定性特性。
