Departamento de Microbiología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.
Curr Pharm Biotechnol. 2011 Aug;12(8):1205-20. doi: 10.2174/138920111796117364.
Bacteriocins are ribosomally synthesized (poly)peptides produced by almost all prokaryotic lineages. Bacteriocins from lactic acid bacteria (LAB) and bacteriocin-producer probiotic organisms have been thoroughly studied due to their wide spectra of action, the long-term use in food fermentations and the consideration of these microorganisms as beneficial for human beings. Most of the studies on the biotechnological application of diverse bacteriocins have been focused on their use as food preservatives, nisin being the prototype successfully used in alimentation. However, bacteriocins from LAB have demonstrated a remarkable potential as therapeutics for medical or veterinary uses, alone or in combination with classical antimicrobials. Their interest is even higher now that the resistance to the antibacterials used in therapeutics is growing. In this review we explore exciting opportunities for bacteriocin and probiotic applications, highlighting the possibilities for new and innovative research in order to give the necessary attention to this type of natural molecules that exhibit a great potential.
细菌素是由几乎所有原核生物谱系产生的核糖体合成（多）肽。由于其广泛的作用谱、在食品发酵中的长期使用以及将这些微生物视为对人类有益，乳酸菌 (LAB) 和细菌素产生益生菌的细菌素已得到深入研究。不同细菌素的生物技术应用的大多数研究都集中在将其用作食品防腐剂上，而乳链菌肽作为成功用于食品的原型。然而，LAB 的细菌素已显示出作为医学或兽医用途的治疗剂的显著潜力，单独使用或与经典抗生素联合使用。由于治疗用抗生素的耐药性不断增加，它们的兴趣甚至更高。在这篇综述中，我们探讨了细菌素和益生菌应用的令人兴奋的机会，强调了进行新的和创新研究的可能性，以便对这类具有巨大潜力的天然分子给予必要的关注。
