Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Brno, Czech Republic.
Expert Rev Anti Infect Ther. 2021 Mar;19(3):309-322. doi: 10.1080/14787210.2020.1816824. Epub 2020 Sep 22.
The emergence and spread of antibiotic resistance among pathogenic bacteria drives the search for alternative antimicrobial therapies. Bacteriocins represent a potential alternative to antibiotic treatment. In contrast to antibiotics, bacteriocins are peptides or proteins that have relatively narrow spectra of antibacterial activities and are produced by a wide range of bacterial species. Bacteriocins of are historically classified as microcins and colicins, and, until now, more than 30 different bacteriocin types have been identified and characterized.
We performed bibliographical searches of online databases to review the literature regarding bacteriocins produced by with respect to their occurrence, bacteriocin role in bacterial colonization and pathogenicity, and application of their antimicrobial effect.
The potential use of bacteriocins for applications in human and animal medicine and the food industry includes (i) the use of bacteriocin-producing probiotic strains, (ii) recombinant production in plants and application in food, and (iii) application of purified bacteriocins.
病原菌对抗生素耐药性的出现和传播促使人们寻找替代抗菌疗法。细菌素代表了一种替代抗生素治疗的潜在选择。与抗生素不同，细菌素是具有相对狭窄抗菌活性谱的肽或蛋白质，由多种细菌产生。历史上， 被分类为微菌素和肠菌素，到目前为止，已经鉴定和表征了 30 多种不同的细菌素类型。
我们对在线数据库进行了文献检索，以回顾关于 产生的细菌素的文献，这些细菌素与它们在细菌定植和致病性中的作用以及它们的抗菌作用的应用有关。
细菌素在人类和动物医学以及食品工业中的潜在应用包括 (i) 利用产细菌素的益生菌菌株，(ii) 在植物中的重组生产和在食品中的应用，以及 (iii) 纯化细菌素的应用。
