巨细胞病毒 e127 蛋白与抑制性 CD200 受体相互作用。
Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.
机构信息
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.
出版信息
J Virol. 2011 Jun;85(12):6055-9. doi: 10.1128/JVI.00064-11. Epub 2011 Apr 6.
Abstract
CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus.
摘要
CD200 是一种细胞表面糖蛋白，可与髓样细胞上的抑制性受体 (CD200R) 结合。CD200 的同源物存在于许多病毒物种中，我们发现大鼠巨细胞病毒 CD200 同源物 (e127) 在感染细胞的细胞表面表达。它与宿主 CD200R 的结合亲和力与宿主蛋白相同，因此该蛋白作为宿主蛋白的紧密模拟物，有可能下调对病毒的免疫反应。
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3
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4
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5
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