Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong.
Hong Kong Med J. 2011 Apr;17(2):112-8.
To evaluate the efficacy and toxicities of stereotactic radiotherapy for unresectable hepatocellular carcinoma.
Retrospective study.
Prince of Wales Hospital, Hong Kong.
Treatment outcome and toxicities.
During the period of 2000 to 2004, 16 patients with hepatocellular carcinoma treated with stereotactic radiotherapy were reviewed.
Of the 16 patients, 11 had assessable responses. For local control, there were two complete and three partial responses, five with stable disease and one with progressive disease, giving a local response rate of 45% and control rate of 91%. The median survival was 23 months. The 1-year and 3-year overall survival rates were 62% and 28%, respectively. The most frequent site of recurrence was intrahepatic but outside the irradiated field. Two patients with Child-Pugh B cirrhosis developed radiation-induced liver disease. No other grade 3/4 toxicities were recorded.
Stereotactic radiotherapy gives high local control rates and has the potential to prolong survival in patients with hepatocellular carcinoma. It is safe and tolerable in Child-Pugh A patients.
评估立体定向放疗治疗不可切除肝癌的疗效和毒性。
回顾性研究。
中国香港威尔士亲王医院。
治疗结果和毒性。
2000 年至 2004 年间，我们对 16 例接受立体定向放疗的肝癌患者进行了回顾性分析。
16 例患者中，11 例可评估疗效。局部控制方面，完全缓解 2 例，部分缓解 3 例，疾病稳定 5 例，疾病进展 1 例，局部缓解率为 45%，局部控制率为 91%。中位生存期为 23 个月。1 年和 3 年总生存率分别为 62%和 28%。最常见的复发部位是肝内但在照射野外。2 例 Child-Pugh B 级肝硬化患者出现放射性肝损伤。未观察到其他 3/4 级毒性。
立体定向放疗可获得较高的局部控制率，并有可能延长肝癌患者的生存时间。在 Child-Pugh A 级患者中，它是安全且耐受良好的。
