Department of Neurosurgery, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
Hong Kong Med J. 2011 Apr;17(2):147-50.
A 31-year-old Chinese man with intractable severe, lifelong Tourette's syndrome characterised by forceful self-injurious motor tics and socially embarrassing vocal tics was treated with bilateral deep brain stimulation. Electrodes were implanted into the thalamic targets at the centromedian-parafascicular complex according to Hassler's nomenclature. A dramatic reduction of tics resulted. At 18 months postoperatively, there was an 81% improvement in his total tics count and a 58% improvement in his Yale Global Tic Severity Scale. His modified Rush video scale decreased from 13 to 8 and visual analogue scale from 10 to 3. These data show that bilateral deep brain stimulation of the thalamus can have a favourable immediate effect on severe tics in a selected group of adult patients suffering from intractable Tourette's syndrome and postoperatively the beneficial effects persisted for at least 18 months.
一位 31 岁的中国男性患有难治性严重终生图雷特氏综合征，其特征为强烈的自伤性运动抽搐和社交尴尬的发声抽搐，接受了双侧深部脑刺激治疗。根据哈斯勒的命名法，将电极植入丘脑的中央中旁核靶点。抽搐明显减少。术后 18 个月，他的总抽搐次数改善了 81%，耶鲁整体抽动严重程度量表改善了 58%。他的改良 Rush 视频量表从 13 降至 8，视觉模拟量表从 10 降至 3。这些数据表明，丘脑双侧深部脑刺激对一组患有难治性图雷特氏综合征的成年患者的严重抽搐具有有利的即时效果，并且术后至少 18 个月内仍能持续获益。
