Sanchez-Margallo Francisco M, Perez Francisco J, Sanchez Miguel A, Asencio Jose Manuel, del Carmen Tejonero Maria, Moreno Carlos, Noguera Jose
Department of Laparoscopic Surgery, Minimally Invasive Surgery Centre Jesús Usón, Cáceres, Spain.
Surg Laparosc Endosc Percutan Tech. 2011 Apr;21(2):e65-9. doi: 10.1097/SLE.0b013e31820a2079.
The purpose of this study was to evaluate the feasibility of hybrid natural orifice translumenal endoscopic surgery (NOTES) transvaginal cholecystectomy in a porcine model of acute cholecystitis. We have developed an experimental model of acute cholecystitis in 8 female pigs (33.37±3.11 kg) through the surgical occlusion of the common bile duct. After 4 days, hybrid NOTES cholecystectomy was performed in all animals with the assistance of only one 5 mm trocar. The transvaginal approach and the abdomen exploration were performed without any complication. The hybrid NOTES cholecystectomy was successfully completed in all animals. The mean operative time was 76.50±10 minutes. Gallbladder rupture appeared in 2 cases, and there was no bleeding or laceration of adjacent organs. Our experiments showed the feasibility of hybrid NOTES cholecystectomy in an experimental model of acute cholecystitis. Additional research and training on experimental models of pathology will be necessary to validate NOTES surgery.
本研究的目的是评估在急性胆囊炎猪模型中，经阴道行混合式经自然腔道内镜手术（NOTES）胆囊切除术的可行性。我们通过手术结扎胆总管，在8只雌性猪（体重33.37±3.11千克）中建立了急性胆囊炎实验模型。4天后，在仅使用一个5毫米套管针辅助的情况下，对所有动物实施了混合式NOTES胆囊切除术。经阴道入路和腹腔探查均未出现任何并发症。所有动物均成功完成了混合式NOTES胆囊切除术。平均手术时间为76.50±10分钟。2例出现胆囊破裂，未发生邻近器官出血或撕裂。我们的实验表明，在急性胆囊炎实验模型中，混合式NOTES胆囊切除术是可行的。要验证NOTES手术，还需要对病理实验模型进行更多研究和培训。
