Schulz R, Bläsig J, Laschka E, Herz A
Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct;305(1):1-4. doi: 10.1007/BF00496998.
The site of action of naloxone to induce jumping in morphine tolerant/dependent rats appears to be dissociated from structures where apomorphine initiates its action to reinduce jumping in previously withdrawn animals. These findings suggest that dopaminergic pathways do not directly affect the neuronal circuit involved in withdrawal jumping behavior, but instead exert a facilitatory influence on neurons that become supersensitive during the state of withdrawal. Thus, an increased response to apomorphine during naloxone-precipitated opiate withdrawal does not necessarily imply a specific supersensitivity of the dopaminergic system.
纳洛酮诱导吗啡耐受/依赖大鼠跳跃的作用位点似乎与阿扑吗啡引发其作用以重新诱导先前戒断动物跳跃的结构无关。这些发现表明，多巴胺能通路并不直接影响参与戒断跳跃行为的神经回路，而是对在戒断状态下变得超敏的神经元发挥促进作用。因此，在纳洛酮诱发的阿片类药物戒断期间对阿扑吗啡反应增强并不一定意味着多巴胺能系统存在特定的超敏反应。
