地塞米松对抑郁症患者下丘脑-垂体-甲状腺轴功能的抑制作用。
Suppressive effects of dexamethasone on hypothalamic-pituitary-thyroid axis function in depressed patients.
作者信息
Maes M, Vandewoude M, Schotte C, Martin M, Blockx P
机构信息
Department of Psychiatry, University Hospital of Antwerp, Edegem, Belgium.
出版信息
J Affect Disord. 1990 Sep;20(1):55-61. doi: 10.1016/0165-0327(90)90049-e.
This study investigated the effects of dexamethasone (1 mg orally) on the function of the hypothalamic-pituitary-thyroid (HPT) axis. We determined pre- and post-dexamethasone thyroid-secreting hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), reverse T3 and cortisol levels in 61 depressed inpatients. Dexamethasone had a pronounced suppressive effect on basal TSH and FT3 levels. It had a significant stimulating effect on rT3 levels. No differences were found between melancholic and minor depressives in the effects of dexamethasone on basal TSH, FT3 and rT3. Cortisol non-suppressors were characterized by less suppression of basal TSH values.
本研究调查了地塞米松（口服1毫克）对下丘脑-垂体-甲状腺（HPT）轴功能的影响。我们测定了61例抑郁症住院患者在地塞米松治疗前后的甲状腺分泌激素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、反三碘甲状腺原氨酸（rT3）和皮质醇水平。地塞米松对基础TSH和FT3水平有显著的抑制作用。它对rT3水平有显著的刺激作用。在忧郁症患者和轻度抑郁症患者中，地塞米松对基础TSH、FT3和rT3的影响没有差异。皮质醇不抑制者的特征是基础TSH值的抑制作用较小。
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