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Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome.

作者信息

Davisson M T, Schmidt C, Akeson E C

机构信息

Jackson Laboratory, Bar Harbor, Maine 04609.

出版信息

Prog Clin Biol Res. 1990;360:263-80.

PMID:2147289
Abstract
摘要

相似文献

1
Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome.小鼠16号染色体节段性三体:一种研究唐氏综合征的新模型系统。
Prog Clin Biol Res. 1990;360:263-80.
2
Segmental trisomy as a mouse model for Down syndrome.节段性三体综合征作为唐氏综合征的小鼠模型。
Prog Clin Biol Res. 1993;384:117-33.
3
Mouse trisomy 16 as an animal model of human trisomy 21: a new approach for studying the pathogenesis of Down syndrome.
Mead Johnson Symp Perinat Dev Med. 1983(22):23-7.
4
Models for Down syndrome: chromosome 21-specific genes in mice.
Prog Clin Biol Res. 1990;360:215-32.
5
Genetics. The critical region in trisomy 21.遗传学。21三体综合征的关键区域。
Science. 2004 Oct 22;306(5696):619-21. doi: 10.1126/science.1105226.
6
Molecular aspects of Down syndrome.
Indian Pediatr. 2005 Apr;42(4):339-44.
7
[The development of the enteric nervous system in terisomy 16 mice with the occurrence of congenital megacolon].[16三体小鼠先天性巨结肠发生中肠神经系统的发育]
Zhonghua Yi Xue Za Zhi. 1999 Jun;79(6):466-9.
8
Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome.唐氏综合征Ts1Cje节段性三体16小鼠模型中的异常突触可塑性。
Neuropharmacology. 2005 Jul;49(1):122-8. doi: 10.1016/j.neuropharm.2005.02.012.
9
Down syndrome and the trisomy 16 mouse: impact of gene imbalance on brain development and aging.唐氏综合征与16三体小鼠:基因失衡对大脑发育和衰老的影响。
Res Publ Assoc Res Nerv Ment Dis. 1991;69:85-99.
10
Chromosome 21 and down syndrome: from genomics to pathophysiology.21号染色体与唐氏综合征:从基因组学到病理生理学
Nat Rev Genet. 2004 Oct;5(10):725-38. doi: 10.1038/nrg1448.

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Male Down syndrome Ts65Dn mice have impaired bone regeneration.雄性唐氏综合征 Ts65Dn 小鼠的骨再生受损。
Bone. 2025 Mar;192:117374. doi: 10.1016/j.bone.2024.117374. Epub 2024 Dec 13.
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γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.γ-分泌酶调节剂 BPN15606 减少了 Aβ42 和 Aβ40,并改善了唐氏综合征小鼠模型的阿尔茨海默病相关病理。
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Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model.三体和药物调节对唐氏综合征小鼠模型结构、功能、分子和遗传系统的多效性影响。
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