Terada M, Satoh M, Mitsuzane K, Shioyoyama Y, Tsuda M, Kishi K, Maeda M, Momura S, Yamada R
Department of Radiology, Wakayama Medical College, Japan.
Radiat Med. 1990 May-Jun;8(3):79-87.
Thirty-two patients with iliac and femoropopliteal artery occlusions were treated with direct intrathrombotic injection of ultrahigh-dose urokinase (10,000 IU/min). Occlusions ranged from 3 to 25 cm (average 13.3 cm) in length and the total urokinase dose from 120,000 to 1,410,000 IU (average 688,000 IU). The procedure was usually followed by balloon angioplasty to dilate the underlying stenoses. The initial recanalization rate was 96.9%, the two week patency rate 81.3%, and the cumulative one-year patency rate 66.3%. Complications associated with this procedure included three episodes of minimal bleeding, two distal embolisms, one local hematoma, and one low-grade fever. All were well controlled by palliative treatment. Results indicate that this procedure can provide rapid recanalization at a higher success rate and with fewer complications than previously reported.
32例髂动脉和股腘动脉闭塞患者接受了超大量尿激酶（10,000国际单位/分钟）直接血栓内注射治疗。闭塞长度为3至25厘米（平均13.3厘米），尿激酶总剂量为120,000至1,410,000国际单位（平均688,000国际单位）。该操作通常随后进行球囊血管成形术以扩张潜在的狭窄。初始再通率为96.9%，两周通畅率为81.3%，累积一年通畅率为66.3%。与该操作相关的并发症包括3例轻微出血、2例远端栓塞、1例局部血肿和1例低热。所有这些均通过姑息治疗得到良好控制。结果表明，该操作能够以比先前报道更高的成功率和更少的并发症实现快速再通。
