Bartels I, Thiele M, Bogart M H
Institut für Humangenetik, Universitat Göttingen, West Germany.
Am J Med Genet. 1990 Oct;37(2):261-4. doi: 10.1002/ajmg.1320370220.
In a retrospective study, maternal serum levels of chorionic gonadotropin (hCG) and pregnancy specific beta 1-glycoprotein (SP1) from 63 pregnancies with aneuploid fetuses were compared to the levels observed in pregnancies with a chromosomally normal fetus. Thirty-eight percent of the abnormal pregnancies had elevated levels (greater than 2.0 multiples of the normal median [MoM]) of hCG and 14% had depressed levels (less than 0.25 MoM). With a false-positive rate of 5%, 44% of the 42 fetuses with trisomy 21 would have been detected by elevated hCG levels. With the same false-positive rate, only 21% had elevated SP1 levels. hCG was significantly depressed in 12 pregnancies affected by fetal trisomy 18.
在一项回顾性研究中，将63例怀有非整倍体胎儿的孕妇血清绒毛膜促性腺激素（hCG）和妊娠特异性β1-糖蛋白（SP1）水平与怀有染色体正常胎儿的孕妇所观察到的水平进行了比较。38%的异常妊娠hCG水平升高（大于正常中位数的2.0倍[MoM]），14%的hCG水平降低（小于0.25 MoM）。假阳性率为5%时，42例21-三体胎儿中有44%可通过hCG水平升高检测出来。假阳性率相同时，只有21%的胎儿SP1水平升高。12例受18-三体胎儿影响的妊娠中，hCG水平显著降低。
