State Key Laboratory of Virology, College of Pharmacy, Wuhan University, Wuhan 430072, China.
Steroids. 2011 Jun;76(7):709-23. doi: 10.1016/j.steroids.2011.03.015. Epub 2011 Apr 5.
A series of new 16E-arylidene androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activities against the human cancer cell lines SW480, A549, HepG2 and HeLa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC(50) values lower than 20 μM against the four cancer cell lines.
一系列新的 16E-亚烯基雄烷衍生物被合成并进行了表征。使用 MTT 法，在体外对新化合物进行了抗 SW480、A549、HepG2 和 HeLa 人癌细胞系的抗癌活性筛选。体外研究结果表明，一些化合物对四种癌细胞系的 IC50 值均低于 20 μM。
