Department of Psychology, Penn State University, University Park, PA 16802, USA.
Int J Psychophysiol. 2011 Oct;82(1):115-23. doi: 10.1016/j.ijpsycho.2011.03.011. Epub 2011 Apr 21.
In the present study we investigate neural network changes after moderate and severe traumatic brain injury (TBI) through the use of resting state functional connectivity (RSFC) methods. Using blood oxygen level dependent functional MRI, we examined RSFC at 3 and 6 months following resolution of posttraumatic amnesia. The goal of this study was to examine how regional off-task connectivity changes during a critical period of recovery from significant neurological disruption. This was achieved by examining regional changes in the intrinsic, or "resting", BOLD fMRI signal in separate networks: 1) regions linked to goal-directed (or external-state) networks and 2) default mode (or internal-state) networks. Findings here demonstrate significantly increased resting connectivity internal-state networks in the TBI sample during the first 6 months following recovery. The most consistent finding was increased connectivity in both internal and external state networks to the insula and medial temporal regions during recovery. These findings were dissociable from repeat measurements in a matched healthy control sample.
在本研究中，我们通过使用静息态功能连接（RSFC）方法来研究中度和重度创伤性脑损伤（TBI）后的神经网络变化。我们使用血氧水平依赖功能磁共振成像（BOLD fMRI），在创伤后遗忘症缓解后 3 个月和 6 个月时检查了 RSFC。本研究的目的是检查在从严重神经功能障碍中恢复的关键时期，任务无关的区域连接如何变化。这是通过检查在独立的网络中，内在的或“静息”BOLD fMRI 信号的区域变化来实现的：1）与目标导向（或外部状态）网络相关的区域，和 2）默认模式（或内部状态）网络。研究结果表明，在恢复后的头 6 个月内，TBI 样本中的静息连接内部状态网络显著增加。最一致的发现是在恢复期间，内部和外部状态网络与岛叶和内侧颞叶区域的连接增加。这些发现与在匹配的健康对照组中的重复测量结果不同。
