Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines, La Jolla, CA 92037, USA.
Cell Stem Cell. 2011 Apr 8;8(4):347-8. doi: 10.1016/j.stem.2011.03.003.
Several recent reports (Mayshar et al., 2010; Laurent et al., 2011; Lister et al., 2011; Gore et al., 2011; Hussein et al., 2011) uncover genetic and epigenetic alterations in induced pluripotent stem cells, stimulating debate about their future. However, will these important findings really impact what we hope to gain?
最近有几项报告(Mayshar 等人,2010;Laurent 等人,2011;Lister 等人,2011;Gore 等人,2011;Hussein 等人,2011)揭示了诱导多能干细胞中的遗传和表观遗传改变,这引发了关于它们未来的争论。然而,这些重要的发现真的会影响我们希望获得的结果吗?