阻断 HIF1α 活性可消除血液癌症干细胞。
Blocking HIF1α activity eliminates hematological cancer stem cells.
机构信息
Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Cell Stem Cell. 2011 Apr 8;8(4):354-6. doi: 10.1016/j.stem.2011.03.006.
PMID:21474097
Abstract
Selective targeting of cancer stem cells (CSCs) has the potential to prevent cancer relapse. Wang et al. (2011) report that hypoxia-inducible factor 1α (HIF1α) represses Notch signaling to maintain CSC subsets from lymphoma, and that blocking HIF1α activity eliminates lymphoma and human acute myeloid leukemia (AML) CSCs.
摘要
选择性针对癌症干细胞（CSC）有可能预防癌症复发。Wang 等人（2011 年）报告称，缺氧诱导因子 1α（HIF1α）抑制 Notch 信号通路以维持淋巴瘤中的 CSC 亚群，并且阻断 HIF1α 的活性可以消除淋巴瘤和人类急性髓系白血病（AML）的 CSC。
Zotero 插件