Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Postgrad Med. 2011 Mar;123(2):185-90. doi: 10.3810/pgm.2011.03.2277.
To determine the features of postprandial glycemic excursions (PPGEs) in patients with polycystic ovarian syndrome (PCOS) using continuous glucose monitoring (CGM).
Forty-five women with PCOS and normal glucose tolerance and 45 healthy, age-matched women (control group) underwent a 3-day period of blood glucose (BG) monitoring using the CGM system. The glycemic level was calculated as the mean level of 24-hour BG value (MBG), and intra-day glycemic excursions were calculated as standard deviation of BG (SDBG) and mean amplitude of glycemic excursion (MAGE). Postprandial glycemic excursions were characterized by the amplitude of the postprandial BG spike and the interval between the meal and the maximal BG value.
Based on CGM, the times to peak glucose of patients with PCOS after 3 meals were higher than the control group (42 ± 18 min vs 32 ± 12 min, 54 ± 25 min vs 39 ± 18 min, and 45 ± 16 min vs 38 ± 16 min, respectively; P < 0.05), and the amplitude of PPGEs after breakfast was higher than the control group (P < 0.05). However, there were no significant differences between the amplitudes of PPGEs after lunch and dinner compared with the control group (P > 0.05). The 24-hour MBG, SDBG, and MAGE of the patients with PCOS were 5.45 ± 0.51 mmol/L, 0.74 ± 0.32 mmol/L, and 1.83 ± 0.97 mmol/L, respectively, and there were no statistically significant differences compared with the control group (P > 0.05).
Women with PCOS and normal glucose tolerance have changes in PPGEs. Continuous glucose monitoring can detect alterations in a comprehensive and sensitive way.
使用连续血糖监测（CGM）来确定多囊卵巢综合征（PCOS）患者餐后血糖波动（PPGE）的特征。
45 名 PCOS 伴糖耐量正常的女性和 45 名年龄匹配的健康女性（对照组）接受了为期 3 天的 CGM 系统血糖监测。血糖水平计算为 24 小时 BG 值的平均值（MBG），日内血糖波动计算为 BG 的标准差（SDBG）和平均血糖波动幅度（MAGE）。餐后血糖波动特征为餐后 BG 峰值幅度和进餐与最大 BG 值之间的间隔。
基于 CGM，PCOS 患者 3 餐的血糖峰值时间均高于对照组（分别为 42±18 分钟比 32±12 分钟、54±25 分钟比 39±18 分钟、45±16 分钟比 38±16 分钟；P＜0.05），早餐后 PPGE 幅度高于对照组（P＜0.05）。然而，午餐和晚餐后 PPGE 幅度与对照组相比无显著差异（P＞0.05）。PCOS 患者 24 小时 MBG、SDBG 和 MAGE 分别为 5.45±0.51mmol/L、0.74±0.32mmol/L 和 1.83±0.97mmol/L，与对照组相比无统计学差异（P＞0.05）。
糖耐量正常的 PCOS 女性存在 PPGE 变化。连续血糖监测可以全面、敏感地检测到这些变化。
