Neuroscience Research Australia, Sydney, NSW, Australia.
Dement Geriatr Cogn Disord. 2011;31(4):254-8. doi: 10.1159/000327169. Epub 2011 Apr 8.
The motor features of corticobasal syndrome (CBS) are well recognized but the fact that many, if not all, affected patients develop cognitive impairment is still underrecognized. The dementia of CBS overlaps most with a language variant of frontotemporal dementia: progressive nonfluent aphasia (PNFA). The aim of this study was to determine the usefulness of Addenbrooke's Cognitive Examination-Revised (ACE-R) in the evaluation of CBS and to document similarities and differences between CBS and PNFA.
Patients with well-defined CBS or PNFA from two tertiary referral centers were selected along with matched controls.
Twenty-one patients with CBS, 23 patients with PNFA and 47 age- and education- matched controls were included. Both CBS and PNFA groups showed substantial impairment on the ACE-R (f = 17.3-80.2, p < 0.001) and were significantly impaired in all domains (p < 0.001). The only significant difference between CBS and PNFA was in the visuospatial domain (p < 0.009), being worse in CBS. Using a cutoff of 88/89 out of 100, 90% of CBS and 82.6% of PNFA patients were impaired. At this cutoff of 88/89, ACE-R in CBS had sensitivity and specificity values of 91 and 98%, respectively.
皮质基底节综合征（CBS）的运动特征广为人知，但事实上，许多（如果不是全部）受影响的患者都会出现认知障碍，这一点仍未得到充分认识。CBS 引起的痴呆与语言变异型额颞叶痴呆（PNFA）重叠最多。本研究旨在确定 Addenbrooke 认知测验修订版（ACE-R）在 CBS 评估中的有效性，并记录 CBS 和 PNFA 之间的相似点和不同点。
从两个三级转诊中心选择了明确诊断为 CBS 或 PNFA 的患者以及匹配的对照组。
共纳入 21 名 CBS 患者、23 名 PNFA 患者和 47 名年龄和教育程度匹配的对照组。CBS 和 PNFA 组在 ACE-R 上均有明显的损伤（f = 17.3-80.2，p < 0.001），且在所有领域均有明显损伤（p < 0.001）。CBS 和 PNFA 之间唯一的显著差异在于视空间域（p < 0.009），CBS 组的损伤更为严重。使用 100 分中 88/89 的截断值，90%的 CBS 和 82.6%的 PNFA 患者受损。在这个 88/89 的截断值下，ACE-R 在 CBS 中的敏感性和特异性值分别为 91%和 98%。
