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A rare case of microgranular acute promyelocytic leukemia associated with ider(17)(q10)t(15;17) in an old-age patient.

作者信息

Kim Min Jin, Cho Sun Young, Lim Gayoung, Yoon Hoi Soo, Lee Hee Joo, Suh Jin-Tae, Lee Juhie, Lee Woo-In, Cho Kyung Sam, Park Tae Sung

机构信息

Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.

出版信息

Korean J Lab Med. 2011 Apr;31(2):86-90. doi: 10.3343/kjlm.2011.31.2.86.

DOI:10.3343/kjlm.2011.31.2.86
PMID:21474981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3116005/
Abstract

We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/3116005/88ff3220bf28/kjlm-31-86-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/3116005/b9098990b425/kjlm-31-86-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/3116005/88ff3220bf28/kjlm-31-86-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/3116005/b9098990b425/kjlm-31-86-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/3116005/88ff3220bf28/kjlm-31-86-g002.jpg

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Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature.

本文引用的文献

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Cancer Genet Cytogenet. 2010 Sep;201(2):116-21. doi: 10.1016/j.cancergencyto.2010.05.007.
2
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Acta Haematol. 2010;123(3):162-70. doi: 10.1159/000294959. Epub 2010 Mar 11.
3
伴有der(17)ins(17;15)的急性早幼粒细胞白血病微颗粒变异型：一例报告及文献复习
Exp Ther Med. 2015 Sep;10(3):1009-1012. doi: 10.3892/etm.2015.2583. Epub 2015 Jun 18.
4
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