Mazières B, Jung M, Bouteiller G, Blasco A, Vigoni F, Bru J B, Arlet J
Nouv Presse Med. 1978 Sep 30;7(33):2947-8.
Marrow scintigraphy using 99mTc colloids was performed in 20 patients with Paget's disease of bone and compared with skeletal scanning in each of them. As long as the regions explored were haematopoietically active, despite the advanced age of the patients, there was decreased marrow uptake in regions of increased uptake on the skeletal scan. Whilst increased uptake of pyrophosphate reflects bone hyperosteogenesis, decreased uptake of colloids reflects marrow fibrosis, and early histological sign of the disease. This scanning technique could be a new criterion in the surveillance of the therapeutic effectiveness of calcitonins or of diphosphonates.
对20例骨Paget病患者进行了使用99mTc胶体的骨髓闪烁扫描，并将其与每位患者的骨骼扫描结果进行比较。只要所探查的区域具有造血活性，尽管患者年龄较大，但在骨骼扫描摄取增加的区域，骨髓摄取会减少。焦磷酸盐摄取增加反映骨骨质增生，而胶体摄取减少反映骨髓纤维化，这是该疾病的早期组织学征象。这种扫描技术可能成为监测降钙素或双膦酸盐治疗效果的一项新指标。
