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贝伐单抗治疗后转移至眼部的肺癌中的血管共选现象。

Vascular co-option in lung cancer metastatic to the eye after treatment with bevacizumab.

作者信息

Mandelcorn Efrem D, Palestine Alan G, Dubovy Sandor, Davis Janet L

出版信息

J Ophthalmic Inflamm Infect. 2010 Nov 17;1(1):35-8. doi: 10.1007/s12348-010-0013-7.

DOI:10.1007/s12348-010-0013-7
PMID:21475657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3062772/
Abstract

BACKGROUND

Chemotherapy with bevacizumab alters the angiogenic environment, and therefore, the growth and spread of metastases. We present a patient with metastatic lung adenocarcinoma to the eye with findings suggestive of retinal vascular co-option.

METHODS

Case report.

RESULTS

A 57-year-old male, receiving systemic bevacizumab for metastatic lung adenocarcinoma, presented with vitreous opacities and clumped deposits adherent to the retinal vessels. No choroidal metastases were present. Diagnostic vitrectomy yielded cellular evidence of adenocarcinoma, with thyroid transcription factor-1 staining confirming a lung primary.

CONCLUSION

The perivascular growth of small foci of metastatic vitreous cells suggests vascular co-option from the native retinal circulation. Similar modification of metastatic disease by bevacizumab has been observed in animal models and selected human cases.

摘要

背景

使用贝伐单抗进行化疗会改变血管生成环境，进而影响转移灶的生长和扩散。我们报告一例转移性肺腺癌累及眼部的患者，其表现提示视网膜血管共选择现象。

方法

病例报告。

结果

一名57岁男性，因转移性肺腺癌接受全身贝伐单抗治疗，出现玻璃体混浊及附着于视网膜血管的团块状沉积物。未发现脉络膜转移。诊断性玻璃体切除术获得了腺癌的细胞证据，甲状腺转录因子-1染色证实原发于肺。

结论

转移性玻璃体细胞小灶的血管周围生长提示源自视网膜自身循环的血管共选择。在动物模型和部分人类病例中也观察到贝伐单抗对转移性疾病有类似的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/8a7576d00def/12348_2010_13_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/bed147a7a8bb/12348_2010_13_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/cbb7c7d2f463/12348_2010_13_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/598b4b4dfb6d/12348_2010_13_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/8a7576d00def/12348_2010_13_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/bed147a7a8bb/12348_2010_13_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/cbb7c7d2f463/12348_2010_13_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/598b4b4dfb6d/12348_2010_13_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc32/3289238/8a7576d00def/12348_2010_13_Fig4_HTML.jpg

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本文引用的文献

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The imaging and neuropathological effects of Bevacizumab (Avastin) in patients with leptomeningeal carcinomatosis.贝伐珠单抗（阿瓦斯汀）在脑膜转移癌患者中的影像学和神经病理学效应。
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Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung.甲状腺转录因子-1在Ⅰ期肺非小细胞癌中的免疫反应性。
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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.肿瘤发生过程中血管生成开关的模式及新出现的机制。
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