Xiao D
Institute of Basic Medical Sciences, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1990 Aug;12(4):270-3.
The effect of anisodamine on arachidonic acid metabolism in macrophages was studied. The results indicated that the synthesis of PGI2, TXA2 and PGF2 alpha stimulated by phorbol-12-myristate-13-acetate (PMA) and calcium ionophore A23187 was dose and time-dependently inhibited by anisodamine, and preincubation of the cells with anisodamine significantly decreased subsequent PMA and A23187-stimulated synthesis of prostaglandins. An isodamine failed to inhibit exogenous arachidonic acid-stimulated synthesis of prostaglandins. It is suggested that the site of action of anisodamine could be the phospholipase A2 reaction.
研究了山莨菪碱对巨噬细胞花生四烯酸代谢的影响。结果表明，佛波酯（PMA）和钙离子载体A23187刺激的前列环素（PGI2）、血栓素A2（TXA2）和前列腺素F2α（PGF2α）的合成受到山莨菪碱剂量和时间依赖性的抑制，并且细胞预先用山莨菪碱孵育可显著降低随后PMA和A23187刺激的前列腺素合成。樟柳碱未能抑制外源性花生四烯酸刺激的前列腺素合成。提示山莨菪碱的作用位点可能是磷脂酶A2反应。
