Department of Chemical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.
Langmuir. 2011 May 3;27(9):5456-63. doi: 10.1021/la105097d. Epub 2011 Apr 8.
The colloidal stability of polymer-stabilized nanoparticles is critical for therapeutic use. However, phosphates in physiological media can induce polymer desorption and consequently flocculation. Colloidal characteristics of PEO-magnetite nanoparticles with different anchors for attaching PEO to magnetite were examined in PBS. The effects of the number of anchors, PEO molecular weight, and chain density were examined. It was observed that ammonium phosphonates anchored PEO to magnetite effectively in phosphate-containing solutions because of interactions between the phosphonates and magnetite. Additionally, a method to estimate the magnetite surface coverage was developed and was found to be critical to the prediction of colloidal stability. This is key to understanding how functionalized surfaces interact with their environment.
聚合物稳定纳米颗粒的胶体稳定性对于治疗应用至关重要。然而，生理介质中的磷酸盐会诱导聚合物解吸，从而导致絮凝。在 PBS 中检查了具有不同附着 PEO 锚的 PEO-磁铁矿纳米颗粒的胶体特性。研究了锚的数量、PEO 分子量和链密度的影响。观察到在含有磷酸盐的溶液中，铵膦酸盐通过与磁铁矿之间的相互作用有效地将 PEO 锚定在磁铁矿上。此外，还开发了一种估计磁铁矿表面覆盖率的方法，发现该方法对于预测胶体稳定性至关重要。这对于理解功能化表面如何与其环境相互作用至关重要。
