1,4-Dihydropyridine activators in the tiamdipine series.
作者信息
Galletti F, Luchowski E, Triggle D J
机构信息
Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo 14260.
出版信息
Eur J Pharmacol. 1990 Aug 28;185(2-3):157-61. doi: 10.1016/0014-2999(90)90635-j.
PMID:2147653
Abstract
The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and antagonist properties, the latter being exhibited at lower concentrations.
摘要
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