Sound Sleep Health, Seattle, WA 98125, USA.
Curr Pharm Des. 2011;17(15):1426-9. doi: 10.2174/138161211796197133.
After the discovery and characterization of the H(3)R and H(4)R receptors, they have become widely anticipated as potential therapeutic agents in the treatment of sleep disorders. In preliminary studies, histamine H(3) receptor (H(3)R) antagonists and inverse agonists have demonstrated promise in the treatment of sleep disorders associated with excessive daytime sleepiness. This review article summarizes the current research in this area and characteristics of H(3)R and H(3)R antagonists and inverse agonists in development.
组胺 H（3）受体（H（3）R）拮抗剂和反向激动剂在治疗与白天过度嗜睡相关的睡眠障碍方面显示出了一定的潜力。
