单克隆抗体与 DST 的联合抑制了记忆 T 细胞介导的加速排斥反应，从而诱导小鼠心脏移植物的长期接受。
Combination of monoclonal antibodies with DST inhibits accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice.
机构信息
School of Life Sciences, Xiamen University, Fujian Province, China.
出版信息
Immunol Lett. 2011 Aug 30;138(2):122-8. doi: 10.1016/j.imlet.2011.03.009. Epub 2011 Apr 6.
Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor-reactive memory T cells, the mean survival time (MST) of grafts in the anti-CD40L/LFA-1/DST group was 49.8d. Adding anti-CD44/CD70 mAbs to anti-CD40L/LFA-1/DST treatment. The MST was more than 100 d (MST>100 d). Compared with anti-CD40L/LFA-1/DST group, anti-CD40L/LFA-1/CD44/CD70/DST group notably reduced the expansion of memory T cells, enhanced the proportion of CD4+Foxp3+ regulatory T cells (Tregs) and suppressed donor-specific responses. Our data suggest that anti-CD40L/LFA-1/CD44/CD70mAbs and DST can synergistically inhibit accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice.
供体反应性记忆 T 细胞介导的加速排斥反应是移植器官存活的障碍。我们研究了不同单克隆抗体（mAbs）和供体特异性输血（DST）在基于记忆 T 细胞的过继性小鼠模型中的联合应用。在供体反应性记忆 T 细胞存在的情况下，抗 CD40L/LFA-1/DST 组移植物的平均存活时间（MST）为 49.8d。在抗 CD40L/LFA-1/DST 治疗中添加抗 CD44/CD70 mAbs，MST 超过 100d（MST>100d）。与抗 CD40L/LFA-1/DST 组相比，抗 CD40L/LFA-1/CD44/CD70/DST 组显著减少了记忆 T 细胞的扩增，增加了 CD4+Foxp3+调节性 T 细胞（Tregs）的比例，并抑制了供体特异性反应。我们的数据表明，抗 CD40L/LFA-1/CD44/CD70mAbs 和 DST 可以协同抑制记忆 T 细胞介导的加速排斥反应，从而诱导小鼠心脏同种异体移植物的长期存活。
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