The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark.
Cytokine. 2011 Jul;55(1):152-5. doi: 10.1016/j.cyto.2011.03.014. Epub 2011 Apr 7.
Plasma levels of YKL-40 are elevated in patients with systemic infection, inflammatory disorders and cancer. Both monocytes/macrophages, neutrophils, and cancer cells have the capacity to produce YKL-40, but the regulation during the inflammatory response is unknown. To study the possible role of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α in the regulation of YKL-40 plasma levels, we included healthy men, who received either recombinant human (rh)IL-6 (n=6), rhTNF-α (n=8) or vehicle (n=7) for 3h. The plasma levels of IL-6 and TNF-α reached ∼ 150 and ∼ 18 pg/ml, respectively, during the infusions. Following the IL-6 infusion, the plasma level of YKL-40 increased from ∼ 30 to ∼ 57 ng/ml (p<0.05) at 24h, and returned to normal values after 48 h. The plasma level of YKL-40 did not change during TNF-α infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-α, has a key-role in the regulation of plasma YKL-40 levels during inflammation.
YKL-40 蛋白在患有全身感染、炎症性疾病和癌症的患者中的血浆水平升高。单核细胞/巨噬细胞、中性粒细胞和癌细胞均具有产生 YKL-40 的能力，但在炎症反应期间的调控机制尚不清楚。为了研究白细胞介素 6 (IL-6) 和肿瘤坏死因子 (TNF)-α 可能在 YKL-40 血浆水平调控中的作用，我们纳入了健康男性，他们分别接受重组人 (rh)IL-6（n=6）、rhTNF-α（n=8）或载体（n=7）输注 3 小时。在输注过程中，IL-6 和 TNF-α 的血浆水平分别达到约 150 和 18 pg/ml。在 IL-6 输注后，YKL-40 的血浆水平在 24 小时内从约 30 增加到约 57 ng/ml（p<0.05），并在 48 小时后恢复正常。在 TNF-α 输注或载体输注期间，YKL-40 的血浆水平没有变化。这些数据表明，IL-6 而不是 TNF-α，在炎症期间调节 YKL-40 血浆水平中起关键作用。
