Winther K, Jespersen C M, Rydberg B, Thamsborg G, Hedner T
Department of Clinical Chemistry, Frederiksberg and Hvidovre Hospital, Denmark.
Eur J Clin Pharmacol. 1990;39(3):291-3. doi: 10.1007/BF00315114.
The effects of 1 week of treatment with low and moderate doses of verapamil or nifedipine upon platelet function has been studied in 12 healthy volunteers. The ex vivo platelet aggregation threshold for ADP or adrenaline was not altered by verapamil or nifedipine. The plasma concentrations of beta-thromboglobulin and platelet factor 4 were significantly reduced by low but not by moderate doses of verapamil and nifedipine. Low doses of verapamil and nifedipine inhibit in vivo platelet activity in healthy volunteers.
在12名健康志愿者中研究了低剂量和中等剂量维拉帕米或硝苯地平治疗1周对血小板功能的影响。维拉帕米或硝苯地平未改变ADP或肾上腺素的体外血小板聚集阈值。低剂量而非中等剂量的维拉帕米和硝苯地平可显著降低β-血小板球蛋白和血小板因子4的血浆浓度。低剂量的维拉帕米和硝苯地平可抑制健康志愿者体内的血小板活性。
