Yamada K, Fuji K, Nabeshima T, Kameyama T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Neurosci Lett. 1990 Oct 2;118(1):128-31. doi: 10.1016/0304-3940(90)90265-b.
Acute intrastriatal injection of quinolinic acid (QA) caused a significant reduction of choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities as well as a decrease of the specific binding of [3H]hemicholinium-3. Pretreatment with MK-801 completely blocked the QA-induced neurotoxicity. Continuous infusion of QA into the lateral ventricle resulted in a reduction of hippocampal and cortical ChAT activities while GAD activities were unchanged. These results suggest that continuous infusion of QA into the lateral ventricle could be a useful technique for the study of chronic neurodegenerative diseases including Alzheimer's disease.
急性纹状体内注射喹啉酸（QA）导致胆碱乙酰转移酶（ChAT）和谷氨酸脱羧酶（GAD）活性显著降低，以及[3H]半胱氨酸-3特异性结合减少。MK-801预处理完全阻断了QA诱导的神经毒性。将QA持续注入侧脑室导致海马和皮质ChAT活性降低，而GAD活性未改变。这些结果表明，将QA持续注入侧脑室可能是研究包括阿尔茨海默病在内的慢性神经退行性疾病的一种有用技术。
