Tetrahydroaminoacridine potentiates neurotoxicity of quinolinic acid in rat striatum.
作者信息
Zhu S G, McGeer E G, Singh E A, McGeer P L
机构信息
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
出版信息
Neurosci Lett. 1988 Dec 19;95(1-3):252-6. doi: 10.1016/0304-3940(88)90666-0.
PMID:2976129
Abstract
Intraperitoneal injection of 5 mg/kg of tetrahydro-9-amino-acridine (THA) in rats 1 h before intrastriatal injection of 50-150 nmol of quinolinic acid potentiated the local neurotoxicity as indicated by measurements of striatal levels of glutamate decarboxylase and choline acetyltransferase. A larger dose (10 mg/kg) THA had no significant effect. The results are discussed in terms of THA's binding to various elements of the NMDA/sigma receptor complex and reported data on such binding are confirmed.
摘要
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