Klebe Sonja, Henderson Douglas W
Department of Anatomical Pathology, Flinders University of South Australia, Adelaide, SA, Australia.
Recent Results Cancer Res. 2011;189:169-93. doi: 10.1007/978-3-642-10862-4_10.
The early diagnosis of mesothelioma is notoriously difficult, both from a clinical and pathological perspective. Patients often undergo several medical investigations without definitive diagnosis. The discovery of biomarkers that can be assessed in pleural effusions, histological samples, and serum may assist with the difficult early diagnosis of mesothelioma. In this chapter we focus on those markers that have been examined in the setting of either early diagnosis of mesothelioma in symptomatic individuals or that have been proposed as suitable for screening of asbestos-exposed individuals, with an emphasis on cytology and histology.
间皮瘤的早期诊断从临床和病理角度来看都非常困难。患者通常要接受多项医学检查才能确诊。发现可在胸腔积液、组织学样本和血清中评估的生物标志物，可能有助于间皮瘤的早期诊断难题。在本章中，我们重点关注那些在有症状个体的间皮瘤早期诊断背景下进行过研究的标志物，或者那些被提议适用于筛查石棉暴露个体的标志物，重点在于细胞学和组织学方面。
